Long Covid and Brain Gray Matter Loss

A study out of the UK has found a significant number of Covid-19 patients who become hospitalized and recover have a noticeable amount of gray matter lost in their brains. The full study is here, but the important excerpt:

We used structural and functional brain scans from before and after infection, to compare longitudinal brain changes between these 394 COVID-19 patients and 388 controls who were matched for age, sex, ethnicity and interval between scans. We identified significant effects of COVID-19 in the brain with a loss of grey matter in the left parahippocampal gyrus, the left lateral orbitofrontal cortex and the left insula. When looking over the entire cortical surface, these results extended to the anterior cingulate cortex, supramarginal gyrus and temporal pole. We further compared COVID-19 patients who had been hospitalised (n=15) with those who had not (n=379), and while results were not significant, we found comparatively similar findings to the COVID-19 vs control group comparison, with, in addition, a greater loss of grey matter in the cingulate cortex, central nucleus of the amygdala and hippocampal cornu ammonis (all |Z|>3). Our findings thus consistently relate to loss of grey matter in limbic cortical areas directly linked to the primary olfactory and gustatory system.

At the end of the day, Covid-19, even if survived, is not a disease you want. And it’s not just brain matter; People are finding themselves with other very serious long term effects.

Leave a Reply

Your email address will not be published. Required fields are marked *